Joseph Bond was born in Neston to James and Mary Bond. After receiving his medical training in London, he travelled to New York, where he joined the British army. He was at the surrender at the Siege of Yorktown in October 1781. For some time he administered medicine to troops made prisoner with John Burgoyne and Lord Cornwallis.

In 1783 he went to Nova Scotia and in 1802 received a small packet of cowpox vaccine from his brother Norman, a doctor in Bath, and vaccinated an infant against smallpox. This treatment is reputed to be the first use of cowpox vaccine in Canada,